Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...

Factors Affecting Drug Response: Overview

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Novel 4.2 kb deletion of the 3'UTR of <i>RUNX2</i> Gene Causes Cleidocranial Dysplasia: Further Delineation of the Role of yhe 3'UTR.

Balkan journal of medical genetics : BJMG·2026

Same author

HEMORRHAGIC PHEOCHROMOCYTOMA AND SEVERE CAROTID STENOSIS: A MULTIDISCIPLINARY APPROACH TO SURGICAL PRIORITIZATION.

Acta endocrinologica (Bucharest, Romania : 2005)·2025

Same author

IODINATED CONTRAST MEDIA INDUCED THYROID STORM AND ACUTE CORONARY SYNDROME: A CASE REPORT.

Acta endocrinologica (Bucharest, Romania : 2005)·2025

Same author

THE IMPORTANCE OF EARLY DETECTING OF THYROID DYSFUNCTION DURING PREGNANCY AND ASSOCIATION WITH GESTATIONAL DIABETES MELLITUS.

Acta endocrinologica (Bucharest, Romania : 2005)·2025

Same author

Tracking variations in daily questionable health behaviors and their psychological roots: a preregistered experience sampling study.

Scientific reports·2023

Same author

Development of a novel instrument for assessing intentional non-adherence to official medical recommendations (iNAR-12): a sequential mixed-methods study in Serbia.

BMJ open·2023

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

Different medicaments in fetus maturation--corticosteroid usage.

M Gojnic¹, M Brankovic, M Pervulov

¹Institute of Gynecology and Obstetrics, University of Belgrade, Belgrade, Serbia. gojagoya@EUnet.yu

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|March 3, 2009

Summary

Artificial fetal lung maturation using corticosteroids significantly improves pregnancy outcomes in high-risk cases. This method enhances fetal lung development, enabling neonatal survival even before 30 weeks of gestation.

More Related Videos

In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines

In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines

Published on: March 5, 2019

Related Experiment Videos

Last Updated: Jun 25, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

Published on: October 25, 2015

In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines

In Vitro Assays to Evaluate the Migration, Invasion, and Proliferation of Immortalized Human First-trimester Trophoblast Cell Lines

Published on: March 5, 2019

Area of Science:

Perinatology
Neonatalogy
Obstetrics

Background:

High-risk pregnancies pose significant challenges to neonatal outcomes.
Inadequate fetal lung development is a major cause of mortality in preterm infants.
Artificial fetal lung maturation aims to mitigate these risks.

Purpose of the Study:

To evaluate the significance of artificial fetal lung maturation in high-risk pregnancies.
To compare outcomes with and without adequate therapeutic intervention.
To assess the efficacy of corticosteroids in accelerating fetal lung maturity.

Main Methods:

Fetal lung maturation was assessed using the lecithin-sphingomyelin ratio via a foam test on amniotic fluid.
Corticosteroids were administered to the fetus (Group A), mother (Group B), or induced mild asphyxia (Group C).
Pregnancy success and delivery timing differences were analyzed.

Main Results:

The success of artificial fetal lung maturation was demonstrated by successful pregnancy completion.
The study tracked the discrepancies between expected and actual delivery dates.
Outcomes were evaluated based on the chosen method of intervention.

Conclusions:

Artificial fetal lung maturation using corticosteroids is effective in enhancing lecithin and sphingomyelin production.
This intervention enables neonatal survival from as early as 30 weeks of gestation.
The study highlights the critical role of accelerated fetal lung development in improving neonatal survival rates.