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Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
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Empiric therapy for the immunocompromised host.

D Armstrong1

  • 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, Cornell University College of Medicine, New York, New York 10021.

Reviews of Infectious Diseases
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Empiric therapy is crucial for immunocompromised patients, especially those with neutropenia. It involves broad-spectrum antibiotics targeting common pathogens, but preventive hygiene is key.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Pharmacology

Background:

  • Empiric therapy represents a significant advancement in managing immunocompromised patients.
  • It is predominantly used for chemotherapy-induced neutropenia, covering common microbial flora.
  • Empiric treatment for opportunistic infections in conditions like HIV is also established.

Purpose of the Study:

  • To review the principles and scope of empiric therapy in immunocompromised hosts.
  • To highlight the importance of considering specific pathogens based on host immune status and environmental factors.
  • To emphasize the role of preventive measures in managing opportunistic infections.

Main Methods:

  • Review of current clinical practices in empiric antibiotic and antifungal therapy.
  • Analysis of factors influencing the selection of empiric regimens.
  • Consideration of environmental exposures and host immune defects.

Main Results:

  • Empiric regimens typically cover common bacterial and fungal flora from the bowel, skin, and catheters.
  • Treatment for opportunistic infections like Pneumocystis pneumonia and Toxoplasma CNS infections is common in HIV patients.
  • Environmental factors and specific immune defects necessitate tailored empiric approaches.

Conclusions:

  • Empiric therapy requires careful consideration of patient-specific immune defects and environmental exposures.
  • The spectrum of opportunistic pathogens varies geographically and institutionally.
  • Preventive strategies, including hygiene, can reduce the need for empiric treatment.