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Published on: April 21, 2022
Multicystic peritoneal mesothelioma: report of three cases
S Charfi1, B Chetaille, M Marcy
1Department biopathology, Paoli-Calmettes Institute, 232 Bd St-Marguerite, 13273, Marseille, Cedex 9, France. charfislim@gmail.com
Abstract:
Multicystic peritoneal mesothelioma is a rare lesion occurring mainly in women in a reproductive age. Its pathogenesis is unclear. We report three cases of multicystic peritoneal mesothelioma in patients that were 28, 38 and 47 years of age (one male, two females). A history of abdominal surgery was reported in two cases. Explorative laparotomy was presumptive of a pseudomyxoma peritoni in two cases, and hyperthermic intraperitoneal chemotherapy was performed. Histological examination demonstrated multicystic lesions with mesothelial cells lining confirmed by immunohistochemical analysis. Unusual findings such as hyperplasia, hobnail features, cytoplasmic vacuolisation and papillary pattern were occasionally noted. The clinical presentation, pathogenesis and pathologic features including differential diagnosis of multicystic peritoneal mesothelioma are discussed.
Insights
Multicystic peritoneal mesothelioma, a rare condition primarily affecting women, presents unique pathological features. This report details three cases, discussing clinical presentation, pathogenesis, and differential diagnosis for this uncommon mesothelial tumor.
Area of Science:
- Oncology
- Pathology
- Gastroenterology
Background:
- Multicystic peritoneal mesothelioma (MPM) is a rare neoplasm predominantly seen in women of reproductive age.
- The pathogenesis of MPM remains largely unknown, contributing to diagnostic challenges.
Observation:
- This study presents three cases of MPM in patients aged 28, 38, and 47 years (one male, two females).
- Two patients had a history of abdominal surgery, and initial diagnoses during laparotomy were often pseudomyxoma peritoni.
- Histological examination revealed multicystic lesions lined by mesothelial cells, confirmed via immunohistochemistry.
Findings:
- Unusual histological features were observed, including hyperplasia, hobnail changes, cytoplasmic vacuolization, and papillary patterns.
- Immunohistochemical analysis confirmed the mesothelial origin of the cells lining the cysts.
Implications:
- Understanding the diverse pathological features of MPM is crucial for accurate diagnosis and effective patient management.
- Further research into the pathogenesis of MPM may elucidate its origins and inform treatment strategies.
