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Updated: Jun 25, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
[Effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats]
Bang-xiang Yang1, Yu Li, Ren Liao
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To determine the effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats and its role in lipotoxic heart disease.
Methods:
Twenty four female Zucker rats were divided into four groups: lean rats+vehicle, lean rats+clofibrate, obese rats + vehicle, obese rats+clofibrate. Daily intraperitoneal injection of clofibrate (300 mg/kg) or vehicle (olive oil, 1 mL/kg) was given to the rats for two weeks. Plasma glucose, insulin, free fatty acids, triglycerdies, cholesterol, and cardiac triglycerdies and fatty acids were measured.
Results:
Clofibrate normalized plasma free fatty acid and cholesterol and reduced plasma triglyceride and insulin in obese rats. However, clofibrate led to accumulation of heart TG and increased myocardial long-chain unsaturated and monounsaturated fatty acids in obese rats.
Conclusion:
Clofibrate aggravates myocardial triglyceride accumulation in female obese Zucker rats. Further studies are needed for the use of clofibrate in treating cardiac lipid accumulation.
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