Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural insights into the interaction of human IgG1 with FcγRI: no direct role of glycans in binding.

Acta crystallographica. Section D, Biological crystallography·2015
Same author

[Qibaipingfei Capsule down-regulate the levels of calcineurin and nuclear factor of activated T-cells isoform c3 (NFATc3) in chronic obstructive pulmonary disease].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2015
Same author

Short-Term Prognosis of Mechanically Ventilated Patients With Guillain-Barré Syndrome Is Worsened by Corticosteroids as an Add-On Therapy.

Medicine·2015
Same author

CUGBP1 and HuR regulate E-cadherin translation by altering recruitment of E-cadherin mRNA to processing bodies and modulate epithelial barrier function.

American journal of physiology. Cell physiology·2015
Same author

Abnormal Methylation Status of the GNAS Exon 1A Region in Pseudohypohyperparathyroidism Combined With Turner Syndrome.

The American journal of the medical sciences·2015
Same author

Endobronchial Ultrasound Elastography for Diagnosing Mediastinal and Hilar Lymph Nodes.

Chinese medical journal·2015

Related Experiment Video

Updated: Jun 25, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

[Relationship between renal apparent diffusion coefficient and renal interstitial fibrosis: preliminary study].

Jie Zhu1, Xiang-ping Zhou, Rong-bo Liu

  • 1Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|March 4, 2009
PubMed
Summary

Apparent diffusion coefficient (ADC) values in the kidneys correlate with renal interstitial fibrosis (RIF) severity. Renal cortex ADC may be a more sensitive indicator of RIF than renal medulla ADC.

More Related Videos

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
07:02

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Related Experiment Videos

Last Updated: Jun 25, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury
07:02

Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

Published on: February 10, 2026

Area of Science:

  • Nephrology
  • Radiology
  • Medical Imaging

Context:

  • Chronic kidney diseases are characterized by progressive renal interstitial fibrosis (RIF).
  • Accurate assessment of RIF is crucial for disease management and prognosis.
  • Non-invasive imaging biomarkers for RIF are highly desirable.

Purpose:

  • To investigate the relationship between renal apparent diffusion coefficient (ADC) values and the severity of renal interstitial fibrosis (RIF).
  • To determine if renal ADC can serve as a non-invasive marker for RIF grading.

Summary:

  • Renal diffusion-weighted imaging (DWI) was performed on patients with chronic kidney disease and healthy controls.
  • Apparent diffusion coefficient (ADC) values were measured in the renal cortex and medulla.
  • A significant decrease in ADC values was observed with increasing RIF grades, particularly in the renal cortex.

Impact:

  • Renal ADC values, especially in the cortex, show potential as non-invasive biomarkers for assessing RIF severity.
  • This finding could lead to improved monitoring and management of chronic kidney diseases.
  • Further research may validate ADC as a routine diagnostic tool for RIF.