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Published on: June 5, 2019
[Combined indicators for diagnosing immune thrombocytopenic purpura]
Jing Zhou1, Neng-gang Jiang, Ling-han Kuang
1Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To search for the best combined indicators for diagnosing immune thrombocytopenic purpura (ITP).
Methods:
Reticulated platelet (RP), thrombopoietin (TPO), platelet-associated immunoglobulins (PAIgG, by ELISA), mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio(P-LCR) by flow cytometry), and automated blood cytometer were tested in three groups of people: patients with ITP (n=45), healthy people (n=45), and patients without ITP (n=42). Receiver operating characteristic (ROC) curve, LSD-t test, logistic regression, and correlation analysis were performed to identify the best indicators for diagnosing ITP.
Results:
The patients with ITP had higher levels of RP, MPV, PDW, P-LCR, and PAIgG than the healthy people and the patients without ITP (P<0.05). The patients without ITP had higher TPO than the healthy people and the patients with ITP (P<0.05). RP and PAIgG were sensitive indicators to ITP. PR was correlated to the diagnosis of ITP (chi2=10.458, P=0.001).
Conclusion:
Individual indicator has limited diagnostic values for ITP, which could be improved by a combination of the indicators.
