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Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

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Published on: August 24, 2015

[Update on infectious risks associated with blood products].

Richard Traineau¹, Marie-Hélène Elghouzzi, Philippe Bierling

¹Etablissement français du sang Ile-de-France, hôpital Saint-Louis, 75475 Paris Cedex 10, France. richard.traineau@sls.ap-hop-paris.fr

La Revue Du Praticien

|March 4, 2009

Summary

Blood transfusions are very safe due to donor screening, though bacterial contamination is the most frequent infectious risk. Emerging infections and variant Creutzfeldt-Jakob disease (vCJD) pose future transfusion risks, with pathogen inactivation as a key strategy.

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Last Updated: Jun 25, 2026

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

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Published on: August 24, 2015

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

Area of Science:

Transfusion Medicine
Infectious Disease Epidemiology
Public Health

Background:

Blood transfusions carry infectious and non-infectious risks, though overall infectious risks are low due to donor selection and screening.
Bacterial contamination is the most frequent infectious risk, but its incidence is declining.
Non-infectious risks like hemolytic reactions and circulatory overload are currently more prevalent than infectious risks.

Purpose of the Study:

To assess the current risks associated with blood transfusion, including infectious and non-infectious agents.
To evaluate the residual risks of transfusion-transmitted infections like HIV, Hepatitis B, and Hepatitis C.
To identify future concerns regarding emerging infections and variant Creutzfeldt-Jakob disease (vCJD) transmission via blood.

Main Methods:

Review of existing data on transfusion-transmitted infections and non-infectious transfusion risks.
Estimation of residual risks for major transfusion-transmitted viral infections.
Analysis of reported cases and concerns regarding vCJD and emerging infectious diseases in transfusion medicine.

Main Results:

Estimated residual risks for transfusion-transmitted HIV, HCV, and HBV are very low (e.g., 1/2,600,000 for HIV).
Bacterial contamination remains the most frequent infectious risk but is decreasing.
Concerns persist regarding transfusion transmission of emerging infections (Dengue, WNV) and vCJD, with limited screening options for the latter.

Conclusions:

Current blood transfusion safety is high due to rigorous screening and donor selection.
Pathogen inactivation technologies are crucial for mitigating future infectious risks, especially for plasma and platelets, with ongoing development for red blood cells.
Addressing emerging infectious diseases and vCJD transmission requires continued vigilance and development of advanced screening and inactivation methods.