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[Phosphate diabetes and Paget's disease: 2 cases].

M Laroche1, J Arlet, J L Ader

  • 1Service de Rhumatologie, CHU, Rangueil, Toulouse.

Revue Du Rhumatisme Et Des Maladies Osteo-Articulaires
|July 1, 1991
PubMed
Summary

This study presents two cases of Paget's disease linked to phosphate diabetes. It explores the possibility that Paget's bone cells secrete a phosphaturic substance.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Nephrology

Background:

  • Paget's disease of bone is a chronic disorder characterized by abnormal bone remodeling.
  • Phosphate diabetes, or renal phosphate wasting, leads to hypophosphatemia.

Observation:

  • Two patients presented with concurrent Paget's disease and phosphate diabetes.
  • These cases suggest a potential link between the two conditions.

Findings:

  • The study investigates the hypothesis that cells affected by Paget's disease may secrete a phosphaturic substance.
  • This substance could contribute to the phosphate wasting observed in phosphate diabetes.

Implications:

  • Understanding this potential mechanism could offer new insights into Paget's disease pathogenesis.
  • Further research may reveal novel therapeutic targets for managing these metabolic bone disorders.

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