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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

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Published on: February 14, 2014

Free testosterone levels, attentional control, and processing speed performance in aging men.

Donel M Martin1, Nicholas R Burns, Gary Wittert

  • 1School of Psychology and Discipline of Medicine, University of Adelaide, SA, Australia. donel.martin@unsw.edu.au

Neuropsychology
|March 4, 2009
PubMed
Summary
This summary is machine-generated.

Lower testosterone levels in aging men are linked to slower cognitive processing speed, potentially due to reduced attentional control. This study explored the neurobiological basis of this association in middle-aged and older men.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Endocrinology

Background:

  • Cognitive functioning declines with age, and processing speed is a key predictor.
  • Neurobiological mechanisms linking processing speed and aging remain unclear.
  • Previous research indicated a negative association between calculated free testosterone levels (cEFT) and processing speed in older men.

Purpose of the Study:

  • To reanalyze previous data to explore the association between cEFT, age, and ex-Gaussian parameters of reaction time (RT).
  • To investigate the role of attentional control in the relationship between cEFT and cognitive functioning in aging men.

Main Methods:

  • Reanalysis of data from 96 middle-to-older aged men.
  • Utilized ex-Gaussian decomposition of reaction time (RT) distributions to estimate distribution skew.
  • Employed path analysis to assess the predictive relationship between cEFT, RT parameters, and cognitive performance.

Main Results:

  • Calculated free testosterone levels (cEFT) were significantly associated with increased skew in the RT distribution, indicating potential attentional control issues.
  • This association between cEFT and RT skew was a strong predictor of processing speed performance.
  • No significant association was found between cEFT and the Gaussian portion of the RT distribution.

Conclusions:

  • Results suggest that cEFT levels influence cognitive functioning in aging males by modulating attentional control processes.
  • Testosterone may play a role in maintaining cognitive processing speed through its effects on attention.
  • Further research is warranted to elucidate the precise neurobiological pathways involved.