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Related Concept Videos

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Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
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Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
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Related Experiment Video

Updated: Jun 25, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
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Abdominal compartment syndrome: pathophysiology and definitions.

Michael L Cheatham1

  • 1Department of Surgical Education, Orlando Regional Medical Center, Orlando, Florida 32806, USA. michael.cheatham@orlandohealth.com

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
|March 4, 2009
PubMed
Summary

Intra-abdominal hypertension (elevated intra-abdominal pressure) and abdominal compartment syndrome can cause organ failure in critically ill patients. Understanding these conditions is key for diagnosis, resuscitation, and preventing end-organ damage.

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A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
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A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg

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Last Updated: Jun 25, 2026

A Case Series of Successful Abdominal Closure Utilizing a Novel Technique Combining a Mechanical Closure System with a Biologic Xenograft that Accelerates Wound Healing
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A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
04:34

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg

Published on: May 31, 2019

Area of Science:

  • Critical Care Medicine
  • Surgical Physiology
  • Gastroenterology

Background:

  • Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are increasingly recognized causes of morbidity and mortality in critically ill patients.
  • Elevated intra-abdominal pressure significantly impairs multiple organ systems, including cardiovascular, pulmonary, renal, and hepatic functions.
  • IAH and ACS pose significant prognostic challenges in intensive care settings.

Purpose of the Study:

  • To present the consensus definitions for the diagnosis and treatment of IAH and ACS.
  • To underscore the importance of understanding the pathophysiologic implications of elevated intra-abdominal pressure.
  • To guide recognition, resuscitation, and prevention strategies for IAH and ACS.

Main Methods:

  • Review and synthesis of current literature on intra-abdominal pressure.
  • Presentation of established consensus definitions for IAH and ACS.
  • Discussion of pathophysiologic mechanisms and clinical implications.

Main Results:

  • IAH is defined as elevated intra-abdominal pressure.
  • ACS is defined as pressure-induced organ dysfunction and failure.
  • Measurement of intra-abdominal pressure is increasingly adopted as a vital sign in at-risk patients.

Conclusions:

  • A comprehensive understanding of IAH and ACS is fundamental for effective patient management.
  • Early recognition and intervention are crucial for improving outcomes in patients with elevated intra-abdominal pressure.
  • Adherence to consensus definitions aids in standardized diagnosis and treatment approaches.