[Therapy with aminoglycoside antibiotics: once daily (q.d.)?]

Theoretical and experimental arguments favor administration of aminoglycosides once daily (q.d.). Results of clinical studies with a limited number of patients support these arguments. However, some practical and clinical questions remain unanswered. Therefore, q.d. infusion of aminoglycosides must still be considered experimental and must remain in the hands of infectious disease specialists until the results of ongoing clinical studies yield the ultimate proof that this novel dosing schedule is as efficacious and no more toxic than the conventional dosing regimens.