Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Special Senses01:26

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive functions.
Perception01:28

Perception

Perception is a fundamental psychological process that enables individuals to organize, interpret, and consciously experience sensory information. This process is crucial for understanding and interacting with the world around us. It includes both bottom-up and top-down processing, each playing a distinct role in how we perceive our environment.
Bottom-up processing begins at the sensory level, where receptors detect external environmental stimuli. These could include the tactile sensation of...
What is a Sensory System?01:31

What is a Sensory System?

Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position.
Sensory Perception: Organization of the Somatosensory System01:11

Sensory Perception: Organization of the Somatosensory System

The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the stimulus...
Parallel Processing01:20

Parallel Processing

The brain processes sensory information rapidly due to parallel processing, which involves sending data across multiple neural pathways at the same time. This method allows the brain to manage various sensory qualities, such as shapes, colors, movements, and locations, all concurrently. For instance, when observing a forest landscape, the brain simultaneously processes the movement of leaves, the shapes of trees, the depth between them, and the various shades of green. This enables a quick and...
Sensory Modalities01:15

Sensory Modalities

Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A systems framework for investigating the roles of multiple transporters and their impact on drug resistance.

Integrative biology : quantitative biosciences from nano to macro·2024
Same author

The interaction of core modules as a basis for elucidating network behavior determining Parkinson's disease pathogenesis.

CPT: pharmacometrics & systems pharmacology·2024
Same author

A unified approach to dissecting biphasic responses in cell signaling.

eLife·2023
Same author

Is an Antireflux Procedure Necessary for a Successful Appendicostomy? The Simplified Malone Antegrade Continence Enema Procedure.

Journal of Indian Association of Pediatric Surgeons·2023
Same author

Network regulation meets substrate modification chemistry.

Journal of the Royal Society, Interface·2023
Same author

Spatial localisation meets biomolecular networks.

Nature communications·2021
Same journal

Evolution of quantitative traits: exploring the ecological, social and genetic bases of adaptive polymorphism.

Journal of theoretical biology·2026
Same journal

The male-biased sex ratio in humans and its role in the transition from promiscuity to pair bonding.

Journal of theoretical biology·2026
Same journal

Quantifying the counter-intuitive effects of vaccination by coupling the transmission dynamics of COVID-19 and the evolution of human behaviors.

Journal of theoretical biology·2026
Same journal

An integrative model of FGF2-induced signaling and muscle cell proliferation.

Journal of theoretical biology·2026
Same journal

A hybrid reaction-diffusion and mechanical stimulus model for mandibular bone remodeling under chewing and vibratory loading.

Journal of theoretical biology·2026
Same journal

Integrated tick management strategies in fragmented peridomestic environments.

Journal of theoretical biology·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

A Method to Study Adaptation to Left-Right Reversed Audition
07:14

A Method to Study Adaptation to Left-Right Reversed Audition

Published on: October 29, 2018

Signal processing through a generalized module of adaptation and spatial sensing.

J Krishnan1

  • 1Chemical Engineering and Chemical Technology, Centre for Process Systems Engineering and Institute for Systems and Synthetic Biology, Imperial College London, South Kensington Campus, London, UK. krishnan@icex.imperial.ac.uk

Journal of Theoretical Biology
|March 4, 2009
PubMed
Summary
This summary is machine-generated.

Cellular adaptation allows signaling components to respond to changing signals, regardless of their strength. This study presents a general module for robust temporal and spatial signaling responses, revealing complex downstream effects.

More Related Videos

Visualizing Visual Adaptation
04:43

Visualizing Visual Adaptation

Published on: April 24, 2017

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

Related Experiment Videos

Last Updated: Jun 25, 2026

A Method to Study Adaptation to Left-Right Reversed Audition
07:14

A Method to Study Adaptation to Left-Right Reversed Audition

Published on: October 29, 2018

Visualizing Visual Adaptation
04:43

Visualizing Visual Adaptation

Published on: April 24, 2017

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

Area of Science:

  • Cellular and Molecular Biology
  • Systems Biology
  • Biophysics

Background:

  • Signal transduction pathways often exhibit adaptation, enabling cells to respond to dynamic environmental cues.
  • Adaptation allows cellular components to maintain sensitivity to signal variations rather than absolute levels.

Purpose of the Study:

  • To develop a generalized module for robust temporal and spatial signal adaptation in cellular processes.
  • To investigate the diverse behaviors and parameter-dependent responses of this module to various input signals.
  • To understand the implications of adaptation for signal processing and downstream cellular responses.

Main Methods:

  • Mathematical modeling and simulation of a generalized adaptation module.
  • Analysis of module behavior under temporal, spatial, and spatio-temporal input signals.
  • Systematic examination of parameter roles in signal processing and propagation.

Main Results:

  • The generalized module demonstrates robust temporal adaptation and spatial response capabilities.
  • The module exhibits varied behaviors in response to different types of input signals (temporal, spatial, spatio-temporal).
  • Parameter variations significantly influence signal processing, propagation, and downstream effects.

Conclusions:

  • A simple module can explain a wide range of downstream cellular responses to diverse input signals.
  • The presence of adaptive signaling complicates the elucidation of downstream cellular component responses.
  • This framework provides insights into the fundamental principles of adaptive signal processing in biological systems.