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[Epitheliogenesis imperfecta in lambs].

A Tontis1, H Hofstetter

  • 1Institut für Tierpathologie, Universität Bern.

Schweizer Archiv Fur Tierheilkunde
|January 1, 1991
PubMed
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Congenital epitheliogenesis imperfecta, a skin defect, affected twin lambs from the same father in a White Alp sheep herd. Removing the sire stopped further occurrences of this genetic defect.

Area of Science:

  • Veterinary Genetics
  • Dermatology
  • Animal Breeding

Background:

  • Congenital epitheliogenesis imperfecta (EI) is a rare inherited skin disorder affecting livestock.
  • White Alp sheep are a specific breed known for their wool production.

Observation:

  • A herd of 23 White Alp ewes experienced five twin births with congenital epitheliogenesis imperfecta.
  • All affected lambs shared the same sire, suggesting a potential genetic link.
  • Typically, only one twin was affected, with characteristic skin lesions and oral defects.

Findings:

  • Epidermal defects were noted between the coronary groove and carpal/tarsal joints.
  • Exungulation (loss of hooves) and defects in the buccal mucosa (cheeks, palate, tongue) were observed.
  • The condition appeared to be heritable, linked to the sire.

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Implications:

  • Identifying and removing the affected sire from the breeding program halted the occurrence of EI.
  • This suggests a strong genetic basis for this form of epitheliogenesis imperfecta in White Alp sheep.
  • Understanding the genetic transmission can aid in preventing similar congenital defects in livestock populations.