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AMD3100 is a CXCR7 ligand with allosteric agonist properties

Irina Kalatskaya1, Yamina A Berchiche, Stéphanie Gravel

  • 1Department of Biochemistry, Université de Montréal, Montréal, Québec, Canada.

Molecular Pharmacology
|March 4, 2009
PubMed
Summary

The bicyclam AMD3100, an inhibitor of CXCR4, also binds CXCR7. AMD3100 acts as an allosteric agonist for CXCR7, revealing a new signaling pathway and necessitating caution in its use.

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