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Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Adjusting a Traverse

Adjusting a Traverse

In the site survey of a four-sided traverse, internal angles are essential to ensure geometric accuracy. The survey revealed that the sum of the measured internal angles was 359 degrees and 48 minutes, which is 12 minutes less than the expected 360 degrees. This discrepancy signals an error likely arising from measurement inaccuracies during the fieldwork.To rectify this error, the adjustment process involved distributing the 12-minute shortfall equally across the four internal angles. By...

Lumber Defects

Lumber Defects

Lumber defects, which can affect both the appearance and structural integrity of wood, include a variety of growth and manufacturing flaws. Growth defects such as knots and knotholes occur where branches were once attached to the tree trunk, with knotholes forming when these knots fall out. Other natural defects include decay and insect damage, which compromise the wood's strength and durability.
Shakes are minor fractures that run along or across the wood's annual rings, while wane is...

Rotation of Asymmetric Top

Rotation of Asymmetric Top

By definition, a spherically symmetric body has the same moment of inertia about any axis passing through its center of mass. This situation changes if there is no spherical symmetry. Since most rigid bodies are not spherically symmetric, these require special treatment.
The relationship between the angular momentum of any rigid body and its angular velocity, both of which are vectors, involves the moment of inertia. The moment of inertia is a scalar quantity only for spherically symmetric...

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Related Experiment Video

Updated: Jun 25, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

A Notch updated.

An-Chi Tien¹, Akhila Rajan, Hugo J Bellen

¹Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA.

The Journal of Cell Biology

|March 4, 2009

Summary

Notch cell-cell signaling is vital in development and disease. New research reveals complex regulatory layers, including sugar modifications and endosomal transit, that modulate this crucial pathway.

Area of Science:

Molecular Biology
Developmental Biology
Cell Biology

Background:

Notch signaling is a fundamental cell-cell communication mechanism essential for development.
Dysregulation of Notch signaling is implicated in various cancers and genetic disorders.
While core components are known, regulatory mechanisms are complex and context-dependent.

Purpose of the Study:

To explore the intricate layers of regulation governing Notch pathway activity.
To investigate the role of post-translational modifications and intracellular trafficking in Notch signaling.
To understand how cellular context influences Notch pathway modulation.

Main Methods:

Analysis of Notch receptor structure and function.
Investigating glycosylation patterns on the extracellular domain.

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Last Updated: Jun 25, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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Published on: February 28, 2017

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Parameterizing V-notch Weir Equations for Flow Monitoring in a Drainage Control Structure

Published on: April 25, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

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Published on: January 12, 2020

Tracking Notch receptor localization within cellular compartments, including endosomes.

Main Results:

Identified complex glycosylation patterns affecting Notch signaling.
Demonstrated the importance of specific endosomal pathways in Notch transit.
Revealed context-specific modulation of Notch signaling.

Conclusions:

Notch signaling is finely tuned by post-translational modifications and intracellular trafficking.
Endosomal compartments play a critical role in regulating Notch pathway activity.
Understanding these regulatory layers is key for therapeutic interventions in Notch-related diseases.