Bioactive metabolites from Spilanthes acmella Murr
Supaluk Prachayasittikul1, Saowapa Suphapong, Apilak Worachartcheewan
1Department of Chemistry, Srinakharinwirot University, Bangkok, Thailand. supaluk@swu.ac.th
Molecules (Basel, Switzerland)
|March 4, 2009
Summary
Spilanthes acmella Murr. extracts show significant antimicrobial and antioxidant properties, yielding novel bioactive compounds. This medicinal plant offers potential therapeutic value for various applications.
Area of Science:
- Phytochemistry
- Pharmacology
- Natural Products Chemistry
Background:
- Spilanthes acmella Murr. (Compositae) is a traditional medicine with known vasorelaxant and antioxidant effects.
- Previous research indicates potential therapeutic applications for S. acmella extracts.
Purpose of the Study:
- To evaluate the antimicrobial, antioxidant, and cytotoxic activities of S. acmella extracts.
- To identify and characterize novel bioactive compounds from S. acmella.
Main Methods:
- Agar dilution method for antimicrobial assays against 27 microbial strains.
- DPPH and SOD assays for antioxidant property evaluation.
- Bioassay-guided isolation of active compounds.
Main Results:
- Fractions inhibited the growth of tested microorganisms, including Corynebacterium diphtheriae and Bacillus subtilis.
- All tested fractions demonstrated antioxidant properties, with potent radical scavenging activity in the DPPH assay.
- Novel bioactive compounds including phenolics, coumarin, and triterpenoids were isolated and identified.
Conclusions:
- Spilanthes acmella possesses significant antimicrobial and antioxidant activities.
- The study identified novel bioactive metabolites from S. acmella with potential therapeutic value.
- S. acmella is a promising source for developing medicines, cosmetics, supplements, and health foods.
Related Concept Videos
01:22Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
The direct-acting...
The direct-acting...
01:14Drug Metabolism: Phase II Reactions
Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...