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Updated: Jun 25, 2026

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Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
Published on: April 7, 2023
Total syntheses of telisatin A, telisatin B and lettowianthine
Surachai Nimgirawath1, Phansuang Udomputtimekakul
1Department of Chemistry, Faculty of Science, Silpakorn University; Nakorn Pathom 73000, Thailand. surachai@su.ac.th
Molecules (Basel, Switzerland)
|March 4, 2009
Abstract:
Treatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline-2,3-dione. Radical cyclisation of these derivatives with tributyltin hydride and 1,1-azobis(cyclohexanecarbonitrile) afforded telisatin A, telisatin B and lettowianthine.

