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Updated: Jun 25, 2026

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
08:12

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Published on: August 8, 2017

Prions remodel gene expression in yeast.

Mick F Tuite1, Brian S Cox

  • 1Kent Fungal Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK. m.f.tuite@kent.ac.uk

Nature Cell Biology
|March 4, 2009
PubMed
Summary
This summary is machine-generated.

Researchers discovered a new way to control gene transcription in yeast. This involves inherited changes in protein structures within regulatory complexes, offering a novel epigenetic mechanism.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Background:

  • Gene transcription is regulated by epigenetic mechanisms in eukaryotic cells.
  • Understanding global gene transcription control is crucial for molecular biology.

Purpose of the Study:

  • To identify novel mechanisms regulating global gene transcription.
  • To investigate inherited, self-perpetuating changes in transcriptional regulatory complexes.

Main Methods:

  • Analysis of two independent studies in yeast models.
  • Focus on conformational changes in protein components of regulatory complexes.

Main Results:

  • Identified an additional mechanism for controlling global gene transcription.
  • This mechanism involves inherited, self-perpetuating conformational changes in key regulatory complex components.

Conclusions:

  • Yeast studies reveal a new epigenetic regulatory pathway for gene transcription.
  • Inherited conformational changes in regulatory complexes represent a novel control mechanism.