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Updated: Jun 25, 2026
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Primary hyperparathyroidism presenting as delayed fracture union
P S Sauvé1, I G I Suliman, J D Calder
1Department of Trauma and Orthopaedics, North Hampshire Hospitals Foundation NHS Trust, Basingstoke, Hampshire, UK. philsauve@doctors.org.uk
Summary
Primary hyperparathyroidism can cause delayed fracture healing in tibial fractures. Treating the condition led to successful bone union, highlighting the importance of considering metabolic causes for non-healing fractures.
Area of Science:
- Orthopedic Surgery
- Endocrinology
- Metabolic Bone Disease
Background:
- Delayed union of fractures presents a significant clinical challenge.
- Primary hyperparathyroidism is a metabolic disorder affecting calcium homeostasis.
Observation:
- A patient with a tibial fracture experienced delayed union despite stable fixation and absence of infection.
- The patient presented with symptoms suggestive of hypercalcemia, including anorexia, nausea, and constipation.
Findings:
- Biochemical analysis revealed elevated calcium and parathyroid hormone levels.
- A sestamibi scan confirmed a parathyroid adenoma, diagnosing primary hyperparathyroidism.
- Following parathyroidectomy, the tibial fracture demonstrated radiological union and clinical improvement.
Implications:
- This case underscores the importance of investigating metabolic causes, such as primary hyperparathyroidism, in cases of fracture non-union.
- Early diagnosis and management of hyperparathyroidism can facilitate fracture healing.
- Consideration of endocrine disorders is crucial in orthopedic cases with delayed healing.
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