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Updated: Jun 25, 2026
Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
[Frequency of methicilin-resistant Staphylococcus aureus strains in clinical spacimens obtained from hospitalized
Mira Mihajlović-Ukropina1, Deana Medić, Zora Jelesić
1Institut za javno zdravlje Vojovodine, Novi Sad Centar za mikrobiologiju.
Introduction:
Staphylococcus aureus is a major cause of both hospital- and community-acquired infections worldwide. Since the introduction of methicillin into clinical use, methicillin-resistant S. aureus strains have emerged with increasing frequency throughout the world. The aim of the study was to determine frequency of resistance to methicillin and other most commonly used antibiotics of S aureus strains isolated from hospitalized patients.
Material And Methods:
During the period 1.1.-31. 12. 2007, 226 strains of S. aureus isolated from hospitalized patients were tested for their susceptibility to penicillin, methicillin, erythromycin, clindamycin, gentamycin, sulfamethoxazolle-trimethoprim, fusidic acid and vancomycin using disc diffusion technique.
Results:
Resistance to methicillin was detected in 20 (7.5%) S. aureus strains. All of them were susceptible to vancomycin. The resistance to other antimicrobial agents varied from 5% for sulfamethoxazolle-trimethoprim to 75% to gentamycin. Among methicillin susceptible strains, high resistance (84.1%) was found to penicillin only The resistance to other antimicrobial agents was low, ranging from 0 for fusidic acid and vancomycin to 12.2% for gentamycin.
Conclusion:
Our results show low rate of methicillin-resistant S. aureus strains compared to other authors "findings, but also the presence of multidrug-resistant isolates and isolates susceptible to vancomycin only These facts suggest the need for further monitoring of susceptibility in order to take adequate measures to prevent and control spreading of resistant strains.
Insights
Methicillin-resistant Staphylococcus aureus (MRSA) was found in 7.5% of hospital isolates. While vancomycin remained effective, high resistance to penicillin and other antibiotics was observed, necessitating ongoing surveillance.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- Staphylococcus aureus is a significant cause of hospital and community infections globally.
- The emergence of methicillin-resistant S. aureus (MRSA) presents a growing public health challenge.
- Monitoring antibiotic susceptibility patterns is crucial for effective treatment strategies.
Purpose:
- To determine the frequency of methicillin resistance in S. aureus strains isolated from hospitalized patients.
- To assess the susceptibility of these strains to commonly used antibiotics, including vancomycin.
Summary:
- A study of 226 S. aureus strains from hospitalized patients in 2007 found 7.5% resistance to methicillin.
- All methicillin-resistant strains were susceptible to vancomycin.
- High resistance rates were observed for penicillin (84.1%) among methicillin-susceptible strains, and varying resistance to other agents, with vancomycin showing universal susceptibility.
Impact:
- The findings indicate a relatively low rate of MRSA compared to some reports, but highlight the presence of multidrug-resistant strains.
- The continued susceptibility to vancomycin is a critical finding.
- Emphasizes the need for continuous monitoring of antibiotic susceptibility to guide infection control and treatment protocols.
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