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Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Liver Histology01:27

Liver Histology

The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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[Concordance between pathologists in the diagnosis of gastric atrophy according with the OLGA system].

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Diseases associated with HIV infection: study of biopsies and surgical resection specimens at a large general hospital in Mexico City.

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[Morphological abnormalities in liver cirrhosis].

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Related Experiment Video

Updated: Jun 25, 2026

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

[Histological abnormalities in acute and chronic hepatitis].

J Aguirre-García1

  • 1Departamento de Patología, Hospital de Especialidades, Centro Médico Nacional, IMSS, Av. Cuauhémoc 330, México 06720, DF.

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|March 5, 2009
PubMed
Summary

This review details the histological patterns of viral hepatitis, classifying liver damage into acute, fulminant, chronic persistent, and chronic active forms. It also discusses diagnostic challenges, including biopsy limitations and drug-induced changes.

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The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

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Last Updated: Jun 25, 2026

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
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Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
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The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Area of Science:

  • Pathology
  • Hepatology
  • Viral Hepatitis

Context:

  • Liver damage from viral hepatitis presents distinct pathological classifications.
  • Understanding histological patterns is crucial for diagnosing viral hepatitis.
  • Biopsy limitations and drug effects can complicate diagnosis.

Purpose:

  • To review and describe the histological patterns of different viral hepatitis forms.
  • To highlight diagnostic challenges in viral hepatitis pathology.
  • To discuss modifications of histological patterns due to medications.

Summary:

  • Viral hepatitis-induced liver damage is pathologically classified into acute, fulminant, chronic persistent, and chronic active types.
  • The manuscript details the characteristic histological features for each classification.
  • Challenges such as small biopsy size and drug-induced alterations are addressed.

Impact:

  • Provides a comprehensive guide to histological diagnosis of viral hepatitis.
  • Aids pathologists in differentiating viral hepatitis subtypes.
  • Informs clinicians about potential diagnostic pitfalls in viral hepatitis assessment.