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Updated: Jun 25, 2026

Cerebral Ischemic Coma Model Induced by Modified Four-Vessel Occlusion
Published on: July 5, 2024
Pathophysiology of hepatic encephalopathy: studies in autopsied brain tissue from hepatic coma patients
1Laboratory of Neurochemistry, André-Viallet Clinical Research Centre, Hôpital St-Luc (University of Montreal), Montreal, Quebec, Canada H2x 3J4.
Abstract:
The understanding of pathophysiologic mechanisms of several neurological and psychiatric diseases has been derived from measurement of neurochemical parameters in autopsied brain tissue. In this report, the author reviews some neuropathological studies from autopsied patients died in hepatic coma. He mentions and analyze the findings in astrocytes, brain amino acid content, amines and their metabolites, brain enzymes activities, and affinity and density of GABA-benzodiazepine receptor complex as well as muscarinic cholinergic receptor function.
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