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An unexpected Bis-ligation of S-nitrosothiols
Jiming Zhang1, Hua Wang, Ming Xian
1Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
Abstract:
A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.
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