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Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example

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Translocation dynamics with attractive nanopore-polymer interactions.

Kaifu Luo¹, Tapio Ala-Nissila, See-Chen Ying

¹Physics Department, Technical University of Munich, D-85748 Garching, Germany. luokaifu@gmail.com

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|March 5, 2009

Summary

Polymer-pore interactions significantly alter biopolymer translocation through nanopores. Attractive forces change pore-emptying dynamics, impacting overall translocation time and scaling behavior.

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Area of Science:

Biophysics
Polymer Physics
Nanotechnology

Background:

Biopolymer translocation through nanopores is crucial for biological processes and technological applications.
Understanding the factors influencing translocation dynamics is key to controlling and optimizing these processes.

Purpose of the Study:

To investigate the impact of polymer-pore interactions on biopolymer translocation dynamics using simulations.
To elucidate the mechanisms by which attractive interactions affect translocation time and scaling behavior.

Main Methods:

Langevin dynamics simulations were employed to model biopolymer translocation.
The study analyzed the three components of translocation time: pore filling, cis-to-trans transfer, and pore emptying.

Main Results:

Attractive polymer-pore interactions significantly alter translocation dynamics.
Pore emptying dynamics shift from non-activated to activated with increasing attractive interaction strength.
The pore emptying time becomes the dominant factor in total translocation time under strong attraction.

Conclusions:

Attractive interactions lead to nonuniversal translocation time dependence on driving force and chain length.
The findings explain observed differences in translocation scaling between solid-state nanopores and biological channels.
This research provides a mechanistic explanation for experimental observations in biopolymer translocation studies.