Related Experiment Video
Updated: Jun 25, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Chirality of lipids makes fluid lamellar phases piezoelectric
John Harden1, Nicholas Diorio, Alexander G Petrov
1Liquid Crystal Institute and Chemical Physics Interdisciplinary Program, Kent, Ohio 44242, USA.
Abstract:
The role of chirality in membrane-forming lipids is not well appreciated at present. Here we demonstrate that the chirality of phospholipids makes fluid lipid bilayers piezoelectric. Thus, chiral lipids would play a central role in the functioning of cell membranes as active mechanotransducers. By periodically shearing and compressing nonaqueous lamellar phases of left ( L-alpha -phosphatidylcholine), right (D- alpha -phosphatidylcholine), and racemic (DL- alpha -phosphatidylcholine) lipids, we induced a tilt of the molecules with respect to the bilayer's normal and produced electric current perpendicular to the tilt plane, with the chiral lipids only. This effect is due to the Sm-A;{*} phase liquid crystal structure of the bilayers, which under molecular tilt becomes a ferroelectric Sm-C;{*} phase, where the polarization is normal to the tilt plane. This coupling allows for a wide variety of sensory possibilities of cell membranes such as mechanoreception, magnetosensitivity, as well as in-plane proton membrane transport and related phenomena such as adenosine triphosphate (ATP) synthesis, soft molecular machine performance, etc.
Related Concept Videos
Asymmetric Lipid Bilayer
Fluid Mosaic Model
Fluid Mosaic Model
Membrane Fluidity
Membrane Fluidity
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Chirality
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

