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Updated: Jun 25, 2026

Generation and Assembly of Virus-Specific Nucleocapsids of the Respiratory Syncytial Virus
Published on: July 27, 2021
Knot-controlled ejection of a polymer from a virus capsid
Richard Matthews1, A A Louis, J M Yeomans
1Rudolf Peierls Centre for Theoretical Physics, 1 Keble Road, Oxford 0X1 3NP, England, United Kingdom.
Abstract:
We present a numerical study of the effect of knotting on the ejection of flexible and semiflexible polymers from a spherical, viruslike capsid. The polymer ejection rate is primarily controlled by the knot, which moves to the hole in the capsid and then acts as a ratchet. Polymers with more complex knots eject more slowly and, for large knots, the knot type, and not the flexibility of the polymer, determines the rate of ejection. We discuss the relation of our results to the ejection of DNA from viral capsids and conjecture that this process has the biological advantage of unknotting the DNA before it enters a cell.
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