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Updated: Jun 25, 2026
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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
[Genetics of atrial fibrillation]
Kardiologiia
|March 5, 2009
Summary
Genetic analysis reveals that atrial fibrillation (AF) often runs in families. An autosomal dominant inheritance pattern and a specific betai-adrenoreceptor gene variant are linked to AF development.
Area of Science:
- Cardiology
- Genetics
- Molecular Biology
Background:
- Atrial fibrillation (AF) is a common arrhythmia with complex etiology.
- Familial aggregation of AF suggests a genetic component.
- Understanding genetic predictors is crucial for risk stratification.
Purpose of the Study:
- To investigate the familial aggregation of atrial fibrillation.
- To determine the inheritance pattern of idiopathic AF.
- To identify genetic predictors for AF development.
Main Methods:
- Family-based segregation analysis was performed on 103 probands with AF and their relatives.
- A control group of 82 individuals without heart disease and their relatives was included.
- Genetic analysis focused on the Ser49Gly variant of the betai-adrenoreceptor gene.
Main Results:
- Significant familial accumulation of AF was observed in probands with the condition.
- Segregation analysis indicated an autosomal dominant inheritance pattern for idiopathic AF.
- The heterozygous Ser49Gly variant of the betai-adrenoreceptor gene was associated with both primary and secondary AF.
Conclusions:
- Atrial fibrillation exhibits a strong familial aggregation.
- Autosomal dominant inheritance is a key factor in idiopathic AF.
- The Ser49Gly betai-adrenoreceptor gene variant serves as a potential genetic predictor for AF.
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