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Bone mineral density in human immunodeficiency virus-1 infected men with hypogonadism prior to

J Teichmann1, U Lange, T Discher

  • 1Department of Internal Medicine, Medical Clinic C, Ludwigshafen, Germany. J.Teichmann@st.josefskrankenhaus.de

European Journal of Medical Research
|March 5, 2009
PubMed

Insights

HIV-infected men with hypogonadism exhibit significantly altered bone metabolism, including reduced bone formation and increased resorption. This hormonal imbalance contributes to decreased bone mineral density (BMD) before highly-active antiretroviral therapy (HAART).

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • HIV Medicine

Background:

  • Bone metabolism alterations are documented in HIV-infected patients.
  • Sex steroids significantly impact bone mass and turnover.
  • Hypogonadism is prevalent in HIV infection.

Purpose of the Study:

  • To investigate the relationship between hypogonadism and bone metabolism in male HIV-infected patients.
  • To assess bone mineral density (BMD) and markers of bone turnover in relation to testicular function.
  • To evaluate bone health in HIV-positive males prior to highly-active antiretroviral therapy (HAART).

Main Methods:

  • Cross-sectional study of 80 male HIV-infected patients and 20 healthy controls.
  • Analysis of serum and urine for calciotropic hormones and bone metabolism markers.
  • Bone mineral density (BMD) assessment using dual-energy X-ray absorptiometry (DXA).

Main Results:

  • 40% of HIV-infected patients presented with hypogonadism.
  • Hypogonadal patients showed decreased serum osteocalcin and increased urinary crosslinks (p < 0.05).
  • Reduced BMD and a dissociation between bone formation and resorption were more pronounced in hypogonadal patients.

Conclusions:

  • Habitual hypogonadism is a significant factor affecting bone metabolism in male HIV-positive patients.
  • Hormonal imbalances associated with hypogonadism contribute to bone loss.
  • These findings highlight the importance of assessing gonadal function in HIV management.

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