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Related Experiment Video

Updated: Jun 25, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

A calcified neointima--"stent" within a stent.

Clare E Appleby¹, Sanh Bui, Vladimír Dzavík

¹Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Canada.

The Journal of Invasive Cardiology

|March 5, 2009

Summary

De novo atherosclerosis, a rare condition, can develop in coronary stents years after implantation. This case highlights calcified neointima causing restenosis 8 years post-stent deployment.

Area of Science:

Cardiovascular Medicine
Interventional Cardiology
Medical Imaging

Background:

Coronary artery disease is a leading cause of mortality worldwide.
Coronary stents are commonly used to treat stenotic lesions.
Restenosis, or re-narrowing of the artery, can occur after stenting.

Observation:

A patient presented with angina 8 years after initial coronary stent placement.
The patient exhibited symptoms indicative of restenosis.
Diagnostic imaging was performed to evaluate the stent and surrounding vessel.

Findings:

Intravascular ultrasound (IVUS) greyscale imaging revealed significant neointimal tissue within the stent.
Virtual histology (VH) analysis of the IVUS data identified calcification within this neointima.

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The findings suggest de novo atherosclerosis within the stent, characterized by calcification.

Implications:

This case underscores the possibility of late-onset, de novo atherosclerosis within coronary stents.
Calcification of neointima may be a significant factor in late stent failure.
Further research into the mechanisms and management of calcified neointima is warranted.