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Hepatitis C virus genotype in blood donors and associated liver disease in Indonesia

Andi Utama1, Bugi Ratno Budiarto, Dewi Monasari

  • 1Molecular Epidemiology Division, Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Tangerang, Indonesia. autama@mrinstitute.org

Intervirology
|March 5, 2009
PubMed

Insights

Hepatitis C virus (HCV) subtype 1b is common in Indonesian patients with liver disease, increasing with disease severity. This finding is crucial for understanding HCV progression and developing targeted treatments.

Area of Science:

  • Hepatology
  • Virology
  • Genetics

Background:

  • Hepatitis C virus (HCV) infection is a global health concern.
  • Understanding HCV genotype distribution is vital for disease management and treatment strategies.

Purpose of the Study:

  • To determine the prevalence of different HCV genotypes in Indonesia.
  • To explore the association between HCV genotype and the severity of liver disease.

Main Methods:

  • Phylogenetic analysis of NS5B and 5'-UTR regions was used for HCV genotyping.
  • Study included asymptomatic carriers (AC), chronic hepatitis (CH), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) patients.

Main Results:

  • HCV subtype 1b was the most prevalent overall (36.5%).
  • Subtype 1b was significantly associated with advanced liver disease (CH, LC, HCC) and absent in asymptomatic carriers.
  • Prevalence of subtype 1b increased with disease severity: AC < CH < LC < HCC.

Conclusions:

  • HCV subtype 1b is a key genotype in Indonesian patients with significant liver disease.
  • The increased prevalence of subtype 1b correlates with disease progression.
  • Genotype-specific insights can inform clinical management of HCV in Indonesia.
Abstract

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