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Updated: Aug 17, 2026
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
[The radiation-sensitizing effect of isometronidazole following its intravesical application in bladder carcinoma. A
D Kob1, A Lilienthal, H Bauhardt
1Klinik und Poliklinik für Radiologie, Friedrich-Schiller-Universität Jena.
Abstract:
The radiosensitizing efficacy of iso-metronidazole, a 4-nitroimidazole derivative, was evaluated in a prospective clinical phase-II study. The results of combined radiotherapy of 25 patients with bladder cancer were compared with those of a control group of 25 patients treated with radiotherapy only. Tumor regression six months after radiotherapy was used as an endpoint. The surgical procedure was performed as double TUR. Evaluating the local tumor control after additional application of iso-metronidazole a gain factor of 1.2 is obtained.
