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Perfusion changes in gastric adenocarcinoma: evaluation with 64-section MDCT
Jin Yao1, Zhi-gang Yang, Tian-wu Chen
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Abdominal Imaging
|March 5, 2009
Summary
First-pass perfusion CT is a feasible method to assess gastric adenocarcinoma microcirculation. This technique quantifies tumor vascularity and angiogenesis, aiding in understanding gastric cancer development.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Perfusion CT (perfusion computed tomography) is widely used clinically but understudied in gastric cancer.
- This study evaluates the feasibility of first-pass perfusion CT using a volume-based technique for assessing gastric adenocarcinoma microcirculation.
Observation:
- Perfusion CT was performed on 58 gastric adenocarcinoma patients using 64-section MDCT.
- Perfusion parameters including blood volume were computed for tumors and normal gastric walls.
- Comparisons were made between tumor and normal tissue, and between subgroups based on lymph node metastasis and cancer stage.
Findings:
- Gastric adenocarcinoma showed significantly increased blood volume compared to normal stomach tissue (P = 0.004).
- A blood volume cut-off of 10.55 mL/100 g effectively discriminated tumor from normal tissue microcirculation.
- No significant differences in perfusion parameters were observed between tumors with or without lymph node metastases, or between early and advanced stages.
Implications:
- First-pass perfusion CT with whole tumor acquisition is a viable technique for quantifying gastric adenocarcinoma vascularity and angiogenesis.
- This imaging approach can provide valuable insights into the microcirculatory characteristics of gastric tumors.
- Further research may explore the clinical utility of these findings in gastric cancer management.
