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[Influence of JDTL injection on inflammatory factors in rat experimental cerebral ischemia]
Hong Yang1, Yi-jun Zhao, Yong-yan Wang
1Medical Experiment Center of China Academy of Chinese Medical Sciences, Beijing 100700, China. leslie18029@163.com
Objective:
To stydy the protective mechanism of Jiedu Tongluo (JDTL) injection on experimental cerebral ischemia.
Method:
Radioimmunoassay (RIA) was utilized to identify the content of TNF-alpha and IL1-beta in brain tissue of rats suffered from 6 h and 24 h ischemia with MCAO, Enzyme-linked immunoadsordent assay (ELISA) was used to observe the level of MCP-1 and ICMA-1.
Result:
After 6 h and 24 h of ischemia, the increased contents of TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 was observed. JDTL injection dramatically inhibited the increase of TNF-alpha, IL1-beta after 6 h and 24 h of ischemia.
Conclusion:
JDTL injection had inhibiting effect on TNF-alpha, IL1-beta, MCP-1 as well as ICMA-1 caused by cerebral ischemia, the result suggested that JDIL injection can protect cerebral tissue from ischemic injury by inhibiting inflammatory factors.
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