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Updated: Jun 25, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
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Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Clinical study of mild hypothermia treatment for severe traumatic brain injury

Ji-Yao Jiang1

  • 1Department of Neurosurgery, Shanghai Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. Jiangjyb@online.sh.cn

Journal of Neurotrauma
|March 6, 2009
PubMed

Clinical randomized controlled trials (RCTs) suggest that mild hypothermia may improve the outcome of severe traumatic brain injured patients with intracranial hypertension when cooling is maintained for longer than 48 h. However, the results are not yet conclusive, and more RCTs are required. Mild hypothermia significantly decreases intracranial pressure (ICP) values when refractory intracranial hypertension cannot be controlled by conventional measures in patients with severe traumatic brain injury (TBI). Prolonged mild-to-moderate hypothermia may be associated with high incidence of pneumonia and hypokalemia, which should be prevented.

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