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Related Experiment Video

Updated: Jun 25, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

Published on: August 16, 2020

Peritoneal fluid adipokines: ready for prime time?

R Wiest¹, F Leidl, A Kopp

¹Regensburg University Hospital, Regensburg, Germany.

European Journal of Clinical Investigation

|March 6, 2009

Summary

Peritoneal fluid contains various adipokines, with concentrations influenced by body mass index, inflammation, and underlying diseases. These findings suggest a new research area for visceral adipokines in gastrointestinal conditions.

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Identification and Dissection of Diverse Mouse Adipose Depots

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Last Updated: Jun 25, 2026

Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots

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Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Area of Science:

Endocrinology
Gastroenterology
Biochemistry

Background:

Visceral adipose tissues secrete adipokines, but their presence in peritoneal fluid was unknown.
This study investigated novel (cartonectin, omentin) and classical adipokines (leptin, adiponectin, resistin, visfatin) in ascites patients.

Purpose of the Study:

To determine peritoneal fluid concentrations of various adipokines in patients with ascites.
To explore correlations between adipokine levels and clinical parameters.

Main Methods:

Enzyme-linked immunosorbent assay (ELISA) and Western blot were used to measure adipokines.
Ninety-six patients with ascites, predominantly due to liver cirrhosis, were included.

Main Results:

All measured adipokines were detected in ascites fluid with wide variations.
Adipokine levels correlated with body mass index (BMI), inflammation (local and systemic), and serum concentrations.
Resistin, leptin, visfatin, and omentin showed specific correlations with peritonitis, underlying disease, white blood cell count, C-reactive protein, and ascitic albumin.

Conclusions:

Peritoneal fluid adipokine concentrations are individualized and influenced by peritonitis, BMI, and systemic inflammation.
These findings highlight the potential role of the peritoneum and visceral adipokines in gastrointestinal diseases.
This research opens new avenues for understanding adipokine function in peritoneal fluid.