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Updated: Jun 25, 2026

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Normal prostate morphology in relaxin-mutant mice.

Avinash Ganesan¹, Thomas Klonisch, Jonathan T McGuane

¹Department of Zoology, University of Melbourne, Parkville, Vic. 3010, Australia.

Reproduction, Fertility, and Development

|March 6, 2009

Summary

This study investigated the role of relaxin (Rln) and its receptor Rxfp1 in prostate gland development. Researchers found no evidence of prostate abnormalities in mutant mice lacking Rln or Rxfp1, suggesting they do not significantly impact prostate morphology.

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Area of Science:

Reproductive biology
Endocrinology
Urology

Background:

The peptide hormone relaxin (Rln) is present in the prostate and seminal plasma, but its specific function in the prostate remains unclear.
Previous studies suggested potential prostate abnormalities in relaxin-mutant mice (Rln(-/-)), but not in relaxin receptor-mutant mice (Rxfp1(-/-)).

Purpose of the Study:

To comprehensively evaluate the prostate morphology in Rln(-/-) and Rxfp1(-/-) mice across different adult ages.
To assess the impact of exogenous relaxin administration on prostate morphology in Rln(-/-) mice.
To examine prostate morphology in transgenic mice overexpressing relaxin (Tg(Rln)).

Main Methods:

Comparative morphological analysis of anterior, dorsal, and lateral prostate lobes in wild-type, Rln(-/-), and Rxfp1(-/-) mice at 2, 4, 6, 8, and 12 months of age.

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Histological examination of duct morphology, epithelial height, and collagen density.

Administration of exogenous relaxin to Rln(-/-) mice to observe effects on prostate morphology.

Analysis of prostate morphology in Tg(Rln) transgenic mice.

Main Results:

No significant differences in prostate duct morphology, epithelial height, or collagen density were observed between Rln(+/+) and Rln(-/-) mice at any age.
Rxfp1(-/-) mice also exhibited no discernible prostate phenotype.
Exogenous relaxin treatment did not alter prostate morphology or epithelial cell height.
Prostate morphology in Tg(Rln) mice was comparable to wild-type controls.
Relaxin receptor (Rxfp1) was detected in the prostate, but relaxin expression was inconsistent.

Conclusions:

The study found no evidence to support a significant role for relaxin or its receptor Rxfp1 in maintaining prostate gland morphology in adult mice.
These findings challenge previous suggestions of a prostate phenotype in relaxin-mutant mice.