Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Cells of the Epidermis

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Layers of the Epidermis

Layers of the Epidermis

The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Geometric and dosimetric impact of heart and cardiac substructure contouring variability in left-sided breast radiotherapy using VMAT-FFF: A FB versus DIBH analysis.

Radiography (London, England : 1995)·2026

Same author

Ceftriaxone induced pancreatitis: A case report with review of literature.

IDCases·2025

Same author

Pseudoglandular hyperplasia of the conjunctiva: A rare entity.

Journal francais d'ophtalmologie·2024

Same author

Epidemiology of bone tumors in children and adolescents: a retrospective study of 266 patients in the south of Tunisia.

Acta orthopaedica Belgica·2024

Same author

Influence of the drying mode of support on the properties of Pd/Al<sub>2</sub>O<sub>3</sub>-ZrO<sub>2</sub> materials used for methane combustion.

Scientific reports·2023

Same author

ALK-Negative Inflammatory Myofibroblastic Tumor: A Challenging Case in a Premature Newborn.

Journal of neonatal-perinatal medicine·2023

Same journal

[Replacement of the trachea using surgical reconstruction: current state of research].

Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris·2009

Same journal

[Retraction pockets].

Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris·2009

Same journal

[Evaluation of 3D imaging software to study computed tomography images of middle ear defects].

Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris·2009

Same journal

[Solitary neurofibroma of the maxillary sinus].

Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris·2009

Same journal

[Case of complex nasal reconstruction with a three-stage forehead flap after animal bite].

Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris·2009

Same journal

[How to manage acquired stenosis of the external auditory canal].

Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris·2009

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

[Cutaneous basosquamous carcinoma].

H Dhouib¹, M Mnejja, L Ayadi

¹Service d'ORL et chirurgie cervicofaciale, CHU Habib-Bourguiba, 3029 Sfax, Tunisie.

Annales D'Oto-Laryngologie Et De Chirurgie Cervico Faciale : Bulletin De La Societe D'Oto-Laryngologie Des Hopitaux De Paris

|March 6, 2009

Summary

This summary is machine-generated.

Basosquamous carcinoma, a rare aggressive cancer, primarily affects the head and neck in men. This condition shows a high tendency for recurrence, with surgery as the main treatment, often requiring adjuvant radiotherapy.

Related Experiment Videos

Last Updated: Jun 25, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Area of Science:

Dermatology
Oncology

Background:

Basosquamous carcinoma is a rare malignancy predominantly affecting the head and neck in male patients.
It presents unique clinical characteristics and progression patterns.

Observation:

Case 1: A 41-year-old male with temporoparietal basosquamous carcinoma experienced multiple recurrences and distant metastasis, leading to death 10 years post-diagnosis.
Case 2: A 71-year-old male with retroauricular basosquamous carcinoma underwent multiple surgeries and radiotherapy due to persistent local recurrence, eventually developing an untreatable brain invasion.

Findings:

Basosquamous carcinoma exhibits aggressive behavior and a significant propensity for recurrence.
Treatment primarily involves surgical resection, with radiotherapy serving as an adjuvant for high-risk cases.

Implications:

The aggressive nature and recurrence potential of basosquamous carcinoma necessitate vigilant monitoring and potentially multimodal treatment approaches.
Further research is needed to clarify the role of chemotherapy in managing this rare cancer.