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Updated: Jun 25, 2026

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
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Advances in beta-cell imaging.

Anna Moore1

  • 1Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA. amoore@helix.mgh.harvard.edu

European Journal of Radiology
|March 6, 2009
PubMed
Summary
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Researchers are exploring advanced in vivo imaging techniques to non-invasively assess surviving pancreatic beta-cell mass in animal models of diabetes, addressing a critical need for diabetes research.

Area of Science:

  • Endocrinology and Metabolism
  • Medical Imaging
  • Diabetes Research

Background:

  • Diabetes mellitus is characterized by impaired insulin production from pancreatic beta-cells, resulting from cell death or dysfunction.
  • A significant unmet need exists for non-invasive methods to evaluate the quantity of surviving beta-cells in diabetes research and clinical practice.

Purpose of the Study:

  • This review focuses on the application of cutting-edge in vivo imaging modalities.
  • The objective is to estimate and evaluate beta-cell mass within animal models of diabetes.

Main Methods:

  • Exploration of state-of-the-art in vivo imaging techniques.
  • Focus on methods applicable to animal models of diabetes mellitus.
  • Evaluation of techniques for assessing pancreatic beta-cell mass.

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In situ Quantification of Pancreatic Beta-cell Mass in Mice
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Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber
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Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber

Published on: June 11, 2020

Related Experiment Videos

Last Updated: Jun 25, 2026

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets
08:50

Analysis of Beta-cell Function Using Single-cell Resolution Calcium Imaging in Zebrafish Islets

Published on: July 3, 2018

In situ Quantification of Pancreatic Beta-cell Mass in Mice
09:50

In situ Quantification of Pancreatic Beta-cell Mass in Mice

Published on: June 7, 2010

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber
09:07

Longitudinal In Vivo Imaging and Quantification of Human Pancreatic Islet Grafting and Contributing Host Cells in the Anterior Eye Chamber

Published on: June 11, 2020

Main Results:

  • The review synthesizes current advancements in non-invasive imaging for beta-cell mass assessment.
  • Highlights the utility of these methods in preclinical diabetes research.

Conclusions:

  • In vivo imaging offers promising non-invasive strategies for evaluating beta-cell mass.
  • These techniques are crucial for advancing our understanding and treatment of diabetes mellitus.