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Imaging Cleared Intact Biological Systems at a Cellular Level by 3DISCO
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From molecular imaging to systems diagnostics: time for another paradigm shift?

King C P Li1

  • 1Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA. kli@tmhs.org

European Journal of Radiology
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Summary

Molecular imaging, while practiced for decades in nuclear medicine, is a recent concept for radiologists. This article introduces "Systems Diagnostics" to help radiologists translate advanced imaging data into clinical decisions.

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Area of Science:

  • Radiology and Biomedical Imaging
  • Nuclear Medicine
  • Medical Technology

Background:

  • Molecular imaging concepts have long been used in biomedical imaging, particularly nuclear medicine.
  • Recent advancements enable in vivo interrogation of biological events at cellular and molecular levels in four dimensions.
  • Translating these advanced techniques into clinical practice is crucial for revolutionizing healthcare.

Purpose of the Study:

  • Introduce the concept of "Systems Diagnostics".
  • Examine the evolving role of radiologists in interpreting complex imaging data.
  • Explore how radiologists can translate diverse information into actionable medical decisions and therapeutic strategies.

Main Methods:

  • Literature review of molecular imaging advancements.
  • Conceptual framework development for Systems Diagnostics.
  • Analysis of the radiologist's role in data integration and clinical decision-making.

Main Results:

  • Molecular imaging has gained prominence in radiology recently, building on decades of nuclear medicine practice.
  • New imaging technologies offer unprecedented insights into biological processes in vivo.
  • A paradigm shift is needed to integrate these technologies into routine clinical care.

Conclusions:

  • Systems Diagnostics provides a framework for radiologists to manage and interpret complex, multi-source data.
  • Radiologists are positioned to become key translators of advanced imaging information into patient care.
  • Adoption of Systems Diagnostics can enhance healthcare delivery through improved medical decision-making.