Related Experiment Video
Updated: Jun 25, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Estimating age by assessing the ossification degree of cranial sutures with the aid of Flat-Panel-CT
Sebastian Harth1, Martin Obert, Frank Ramsthaler
1Department of Neuroradiology, University of Giessen, Klinikstrasse 29, 35385 Giessen, Germany.
Abstract:
Estimating age from the skeletons of adults is difficult. The accuracy decreases for old age. Ossification of the neurocranial sutures has been used as an age characteristic since Broca's time (1824-1880). Although the sutures traverse the bone, current approaches only encompass the ecto- and endocranial sutures. Evaluating the cross-section of sutures necessitates the destruction of the neurocranium. In the context of the "Digital Forensic Osteology" project that ran in cooperation with the Virtopsy-Project it emerged that the resolution of conventional MSCT-data sets was not high enough to image sutures. The eXplore Locus Ultra (eLU) Flat-Panel-CT-Scanner from GE was used for these experiments. During autopsy, the skullcap was scanned and then immediately returned to the corpse. To date, the skullcaps of 221 individuals have been scanned. The data sets were reconstructed in 3D. The cross sections of the sutures of 14 segments could be evaluated in the cross-sectional view. Seven stages of ossification were defined and each segment was assessed for these. Several regression formulae for age estimation were developed from the results. This examination method is a suitable means for non-invasively evaluating the ossification degree of cranial sutures in the entire cross-section and for the entire calvarium. An increase in the number of examined individuals in this ongoing project and a look at extreme values will further heighten the conclusiveness of the results.
More Related Videos
Related Concept Videos
Sutures of the Skull
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Overview of the Skull
The cranial vault surrounds and protects the brain and houses the middle and inner ear structures. This cavity is bounded superiorly by the rounded top of the skull, which...
Cranial Bones: Superior and Posterior View
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
Cranial Bones: Lateral View
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...

