Inflammatory myofibroblastic tumors in two dogs
1Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand. c.knight@massey.ac.nz
Veterinary Pathology
|March 6, 2009
Summary
Inflammatory myofibroblastic tumors (IMTs) were diagnosed in two dogs based on histopathology and immunohistochemistry. These rare canine tumors show specific cell markers, aiding diagnosis.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Soft Tissue Tumors
Background:
- Inflammatory myofibroblastic tumor (IMT) is a rare neoplastic proliferation of myofibroblastic spindle cells.
- IMT diagnosis in veterinary medicine relies on histopathology and immunohistochemistry.
- Understanding IMT in dogs is crucial for accurate diagnosis and treatment.
Observation:
- Two canine soft tissue masses were examined histopathologically.
- Both masses exhibited well-demarcated, interweaving bland spindle cells with scattered lymphocytes and plasma cells.
- Immunohistochemistry revealed spindle cell expression of vimentin, calponin, smooth muscle actin, and desmin.
Findings:
- Immunohistochemistry confirmed spindle cells reacted strongly to vimentin and calponin.
- A subset of spindle cells expressed smooth muscle actin and desmin.
- Results indicated a myofibroblastic origin, leading to a diagnosis of inflammatory myofibroblastic tumor (IMT).
Implications:
- This study documents the second veterinary case of IMT.
- The findings support IMT as a distinct entity in canine soft tissue tumors.
- Accurate diagnosis of IMT in dogs aids in understanding its behavior and potential therapeutic strategies.
