Clinical biochemistry of assisted conception

Area of Science:

• Reproductive Medicine
• Clinical Biochemistry

Background:

• Assisted reproductive technology (ART) has advanced significantly since 1978.
• Approximately 15% of UK couples face fertility challenges.
• National Health Service (NHS) funding is available for eligible women aged 23-39 for one free in vitro fertilization (IVF) cycle since 2005.

Purpose of the Study:

• To summarize principles of assisted conception.
• To examine the role of the biochemistry laboratory in fertility assessment and treatment.
• To review donor screening and outcomes of children born via ART.

Main Methods:

• Review of assisted conception principles and laboratory roles.
• Focus on biochemical assessments for ovulatory disorders and ovarian reserve.
• Examination of treatment monitoring and donor screening protocols.

Main Results:

• Biochemistry labs are crucial for diagnosing ovulatory disorders.
• Ovarian reserve assessment by biochemistry labs informs fertility treatment decisions.
• Biochemical monitoring aids in managing and optimizing fertility treatments.

Conclusions:

• The biochemistry laboratory is integral to the successful diagnosis and management of infertility.
• Accurate biochemical assessments are vital for personalized fertility treatment plans.
• The laboratory's role extends to ensuring the safety of gamete donation and monitoring ART outcomes.