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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 25, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
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Published on: September 3, 2013

Targeting Clusterin in prostate cancer.

F Rizzi1, S Bettuzzi

  • 1Department of Experimental Medicine, University of Parma, Parma, Italy.

Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society
|March 6, 2009
PubMed
Summary

Clusterin (CLU) protein isoforms arise from complex gene regulation, not alternative splicing. Targeting CLU may offer new prostate cancer therapies, a significant concern for veterans.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Clusterin (CLU) has a poorly understood biological function despite its involvement in crucial cellular processes like proliferation and apoptosis.
  • CLU plays a role in various diseases, including cancer, with its gene encoding multiple protein isoforms.
  • Previous understanding of CLU isoform production via alternative splicing is being revised.

Purpose of the Study:

  • To clarify the molecular mechanisms underlying the production of Clusterin (CLU) protein isoforms.
  • To investigate the complex transcriptional regulation of the CLU gene.
  • To evaluate the therapeutic potential of targeting CLU in prostate cancer, particularly for veterans.

Main Methods:

  • Analysis of CLU gene transcriptional regulation.

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  • Investigation of CLU mRNA transcripts and protein isoforms.
  • Review of existing data on CLU expression in tumors, focusing on prostate cancer.

    • Main Results:

    • The CLU gene produces two distinct transcripts from independent transcriptional start sites, challenging the alternative splicing hypothesis.
    • Multiple CLU protein isoforms with varied sub-cellular localizations and functions are encoded by the CLU gene.
    • CLU expression is deregulated in numerous tumors, notably prostate cancer.

    Conclusions:

    • CLU protein isoforms are generated through complex transcriptional regulation, not alternative splicing.
    • Understanding CLU's role in prostate cancer may lead to novel therapeutic strategies.
    • Targeting CLU presents a potential avenue for treating prostate cancer, a critical health issue for veterans.