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Related Experiment Video

Updated: Jun 25, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Adiponectin and cardiovascular disease.

Rei Shibata¹, Noriyuki Ouchi, Toyoaki Murohara

¹Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. rshibata@med.nagoya-u.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society

|March 6, 2009

Summary

Obesity is linked to cardiovascular issues, with lower adiponectin levels increasing disease risk. This protein shows promise as a therapeutic target for protecting heart and blood vessel health.

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Published on: July 21, 2023

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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

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Published on: June 3, 2019

Isolation, Culture, and Adipogenic Induction of Stromal Vascular Fraction-derived Preadipocytes from Mouse Periaortic Adipose Tissue

Isolation, Culture, and Adipogenic Induction of Stromal Vascular Fraction-derived Preadipocytes from Mouse Periaortic Adipose Tissue

Published on: July 21, 2023

Area of Science:

Cardiovascular Science
Metabolic Disorders
Endocrinology

Background:

Obesity is a significant risk factor for metabolic and cardiovascular diseases.
Adiponectin, an adipose-derived protein, is downregulated in obesity and associated disorders.
Low adiponectin levels correlate with increased prevalence of obesity-linked cardiovascular diseases like ischemic heart disease and peripheral artery disease.

Purpose of the Study:

To investigate the cardiovascular protective effects of adiponectin.
To explore the mechanisms by which adiponectin influences cardiovascular health.
To evaluate adiponectin as a potential therapeutic target for cardiovascular diseases.

Main Methods:

Experimental studies investigating adiponectin's direct effects on cardiovascular cells.
Analysis of adiponectin's role in modulating inflammatory and hypertrophic responses.
Examination of adiponectin's influence on endothelial cell function and signaling pathways.

Main Results:

Adiponectin demonstrates beneficial cardiovascular effects by acting directly on heart and blood vessel cells.
Adiponectin protects cardiovascular tissues against stress through anti-inflammatory and anti-hypertrophic mechanisms.
Adiponectin stimulates endothelial cell responses, partly via modulation of AMP-activated protein kinase signaling.

Conclusions:

Adiponectin possesses significant cardiovascular protective properties.
The beneficial effects of adiponectin are mediated through various cellular and molecular mechanisms.
Adiponectin represents a promising therapeutic target for managing cardiovascular diseases linked to obesity.