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C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese

Qi Wang1, Hu Ding, Jia-rong Tang

  • 1The Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Acta Pharmacologica Sinica
|March 6, 2009
PubMed

Insights

The C-reactive protein (CRP) gene -717A allele may protect against ischemic stroke. The H3 haplotype (G-C-C) is a risk marker, while H5 (A-T-C) may predict hemorrhagic stroke outcomes.

Area of Science:

  • Genetics and Cardiovascular Epidemiology
  • Molecular Biology and Stroke Research

Background:

  • C-reactive protein (CRP) is a key inflammatory marker linked to cardiovascular disease risk.
  • Single-nucleotide polymorphisms (SNPs) in the CRP gene may influence serum CRP levels and disease susceptibility.

Purpose of the Study:

  • To investigate the genetic association between CRP gene SNPs and the risk of ischemic and hemorrhagic stroke.
  • To explore the role of specific CRP gene variants and haplotypes in stroke pathogenesis within the Han Chinese population.

Main Methods:

  • Genotyping of four CRP SNPs (-757A>G, -717A>G, -286C>T>A, +2147C>T) in 564 ischemic stroke patients, 220 hemorrhagic stroke patients, and 564 controls.
  • Utilized TaqMan assays for SNP genotyping and performed haplotype analysis to assess combined SNP effects.

Main Results:

  • The -717A>G polymorphism's A allele showed a protective effect against ischemic stroke (OR=0.28, P=0.003).
  • The H3 (G-C-C) haplotype was associated with an increased risk of ischemic stroke (OR=1.052, P=0.047).
  • Haplotype H5 (A-T-C) frequency differed significantly between ischemic and hemorrhagic stroke patients (P=0.0003).

Conclusions:

  • The CRP gene -717A allele appears to confer a protective effect against ischemic stroke.
  • The H3 haplotype serves as an independent risk marker for ischemic stroke.
  • The H5 haplotype may function as a prognostic marker for hemorrhagic stroke.
Abstract

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