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Updated: Jun 25, 2026

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
Published on: August 21, 2021
Decreasing anastomotic and staple line leaks after laparoscopic Roux-en-Y gastric bypass
Terrence M Fullum1, Kanaychukwu J Aluka, Patricia L Turner
1Department of Surgery, Howard University College of Medicine, Washington, DC, USA. tfullum@howard.edu
Background:
Anastomotic and staple line leaks (ASL) occur after laparoscopic Roux-en-Y gastric bypass (LRYGB) with a reported incidence as high as 6%. Leaks are the second most common cause of post-LRYGB mortality after pulmonary embolism, and can be associated with significant morbidity. Prevention and early detection may limit both morbidity and mortality.
Methods:
A retrospective analysis of prospectively collected data was performed on all LRYGBs performed in a community hospital by a single surgeon from August 2001 to December 2005. All operations were performed using a linear-stapled anastomosis with buttressing material, handsewn otomy closures, stay sutures, intraoperative leak testing, and fibrin sealant.
Results:
760 patients underwent LRYGB during the study period. Eighty-nine percent (n = 674) were female and 11% (n = 86) were male. Mean body mass index (BMI) was 50 kg/m2 (range 36-83 kg/m2). Mean age was 40 years (range 17-72 years). Two patients developed three gastric pouch staple line leaks (0.4%). There were no mortalities.
Conclusion:
Operative technique, including appropriate staple sizing, staple line reinforcement, handsewn otomy closures, placement of stay sutures, intraoperative leak testing, and placement of fibrin sealant contributed to a lower than expected incidence of ASL after LRYGB in this series.
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