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Natural product analysis over the last decades
Andrew Marston1, Kurt Hostettmann
1Laboratory of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.
Planta Medica
|March 6, 2009
Summary
Analytical technology advancements drive natural product chemistry. New high-throughput screening demands more sensitive and selective methods for metabolite identification and structure determination.
Area of Science:
- Natural Product Chemistry
- Analytical Chemistry
- Metabolomics
Background:
- The field of natural product chemistry heavily relies on analytical technology for progress.
- Characterizing metabolites in complex mixtures necessitates sophisticated analytical techniques.
Observation:
- Chromatographic and spectral techniques are crucial for sensitivity, selectivity, and structural information.
- Rapid evolution of analytical methods over 50 years has been observed.
Findings:
- This review highlights key chromatographic and spectral techniques in natural product analysis.
- High-throughput screening programs necessitate more efficient and sensitive methodologies.
Implications:
- Future analytical methods must provide adequate on-line information for metabolite structure determination.
- Continued innovation in analytical technology is essential for advancing natural product research.
