Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
Cationic Chain-Growth Polymerization: Mechanism00:57

Cationic Chain-Growth Polymerization: Mechanism

The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the generated carbocation,...
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
Polymers02:34

Polymers

The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the properties that they exhibit. Additionally,...
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced Lipidomics via False-Positive Filtering and Multilevel Interpretation Reveals Six Mediators Linking Intravenous Omega-3 Lipid Emulsions to Neuropathic Pain Modulation.

Journal of agricultural and food chemistry·2026
Same author

A descriptive multilevel analysis associating COVID-19 with polymyositis: from genetic markers and candidate mediators to clinical hematological profiles.

Frontiers in medicine·2026
Same author

Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis.

Nature communications·2026
Same author

Integrated Mendelian Randomization and Single-Cell RNA Sequencing Analyses Reveal Lactate Metabolism as a Key Pathway in COVID-19-Induced Pulmonary Fibrosis.

Canadian respiratory journal·2026
Same author

Unveiling the secret of cellular metamorphosis: the crucial role of EndMT mechanisms in COVID-19-induced pulmonary fibrosis.

Inflammopharmacology·2025
Same author

Clinical application prospects of traditional Chinese medicine as adjuvant therapy for metabolic reprogramming in colorectal cancer.

Frontiers in immunology·2025

Related Experiment Video

Updated: Jun 25, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Cyclic peptide-polymer complexes and their self-assembly.

Dominique Bélanger1, Xia Tong, Sadia Soumaré

  • 1Laboratoire de synthèse supramoléculaire, Département de chimie Institut de Pharmacologie, Université de Sherbooke, 3001, 12e avenue nord, Sherbrooke, Québec J1H 5N4, Canada.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 6, 2009
PubMed
Summary

Researchers synthesized novel cyclic peptides for polymer interactions. These peptides form self-assembled structures with poly(vinyl alcohol) (PVA), creating ordered filaments via hydrogen bonding.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Related Experiment Videos

Last Updated: Jun 25, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Area of Science:

  • Supramolecular Chemistry
  • Polymer Science
  • Organic Synthesis

Background:

  • Cyclic peptides offer unique structural motifs for self-assembly.
  • Designing peptides for specific interactions with polymers is crucial for advanced materials.
  • Hydrogen bonding is a key interaction for molecular recognition and self-organization.

Purpose of the Study:

  • To synthesize novel chiral cyclic peptides capable of hydrogen-bonding interactions with polymers.
  • To investigate the self-assembly behavior of these peptides when complexed with poly(vinyl alcohol) (PVA).
  • To explore the potential of polymer-mediated self-organization of cyclic peptides.

Main Methods:

  • Synthesis of functionalized cyclic peptides.
  • Complexation studies with poly(vinyl alcohol) (PVA).
  • Characterization of self-assembled structures in solution and on surfaces using techniques like microscopy.

Main Results:

  • A novel cyclic peptide derivative was synthesized and shown to complex with PVA.
  • Extensive hydrogen-bonding interactions were observed between the cyclic peptide and PVA hydroxyl groups.
  • The peptide/PVA complexes self-assembled into ordered aggregates, forming micrometer-long filaments upon surface casting.

Conclusions:

  • Functionalized cyclic peptides can effectively complex with polymers like PVA through hydrogen bonding.
  • Polymers can serve as scaffolds to mediate and control the self-assembly of cyclic peptides.
  • This approach offers a viable strategy for creating ordered nanostructures and materials using peptide-polymer composites.