Severe primary antiphospholipid syndrome.

Area of Science:

• Hematology
• Immunology
• Vascular Medicine

Background:

• Antiphospholipid syndrome (APS) is an autoimmune disorder associated with recurrent thrombosis and/or pregnancy morbidity.
• The precise mechanisms driving thrombosis in APS remain incompletely understood, despite its clinical significance.
• APS presents with diverse thrombotic events, commonly affecting deep veins and arteries.

Observation:

• A 42-year-old female with severe primary Antiphospholipid syndrome was admitted.
• The patient presented with symmetrical peripheral gangrene, a rare clinical manifestation of APS.
• This presentation is unusual compared to the more common deep vein thrombosis or arterial occlusions.

Findings:

• The patient's symmetrical peripheral gangrene was successfully treated.
• This case demonstrates that peripheral gangrene can be a presenting feature of severe primary APS.
• Successful management was achieved despite the uncommon manifestation.

Implications:

• Highlights the varied clinical spectrum of Antiphospholipid syndrome.
• Suggests the need for heightened awareness of uncommon presentations like peripheral gangrene in APS patients.
• Emphasizes the importance of timely diagnosis and treatment for potentially severe manifestations of APS.