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Omegaven for the treatment of parenteral nutrition associated liver disease: a case study

Aaron W Calhoun1, Janice E Sullivan

  • 1Department of Pediatrics, University of Louisville, 571 S. Floyd Street, Ste 332, Louisville, KY 40202, USA. aaron.calhoun@louisville.edu

The Journal of the Kentucky Medical Association
|March 7, 2009
PubMed

Insights

Omegaven, an Omega-3-based lipid emulsion, successfully treated severe liver damage in an infant with Short Gut Syndrome receiving long-term parenteral nutrition. This innovative therapy resolved cholestasis and hepatopathy, potentially preventing the need for organ transplantation.

Area of Science:

  • Hepatology
  • Pediatric Gastroenterology
  • Nutritional Science

Background:

  • Infants with Short Gut Syndrome often require chronic parenteral nutrition (PN), which can lead to severe liver complications like cholestasis and hepatopathy.
  • The management of PN-induced liver disease in pediatric patients presents significant challenges, sometimes necessitating multivisceral organ transplantation.

Observation:

  • A 17-month-old infant with Short Gut Syndrome experienced severe cholestasis and hepatopathy secondary to long-term PN.
  • Treatment with Omegaven, an experimental parenteral lipid formulation rich in Omega-3 triglycerides, was initiated to prevent organ transplantation.

Findings:

  • Within six months of Omegaven administration, the infant's cholestasis resolved, and hepatopathy significantly improved.
  • Omegaven's efficacy is attributed to its Omega-3 fatty acid composition, which enhances fat absorption and modulates inflammatory responses.

Implications:

  • Omegaven shows promise as a therapeutic option for alleviating parenteral nutrition-induced cholestasis in infants.
  • This case highlights the potential of alternative lipid emulsions in managing complex gastrointestinal and liver conditions in pediatric patients.
  • Further clinical trials are warranted to establish the role of Omegaven in treating PN-associated liver disease.

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